Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379711 | 0.96 | HRH3 (0.43) | HRH3APEX1GRK6MAOBKIF11 | |
| SCHEMBL4386828 | 0.89 | HRH3 (0.46) | HRH3APEX1GRK6ALDH1A1HPGD | |
| Oxalic Acid SCHEMBL8934783 | 0.84 | MAPT (0.34) | ALDH1A1HPGDPOLBRAB9AKMT2A | |
| Oxalic Acid SCHEMBL7994745 | 0.81 | GAA (0.46) | HRH3GRK6ALDH1A1POLBKMT2A | |
| Oxalic Acid SCHEMBL4378004 | 0.78 | MAOB (0.47) | HRH3MAOBALDH1A1RAB9AKMT2A | |
| SCHEMBL13636333 | 0.77 | ALDH1A1 (0.47) | MAOBALDH1A1RAB9AKMT2AMEN1 | |
| SCHEMBL11725367 | 0.76 | HDAC1 (0.52) | APEX1MAOBALDH1A1HPGDRAB9A | |
| SCHEMBL4379687 | 0.75 | KMT2A (0.50) | HRH3MAOBALDH1A1RAB9AKMT2A | |
| SCHEMBL4543312 | 0.74 | KMT2A (0.49) | HRH3MAOBALDH1A1KMT2AMEN1 | |
| SCHEMBL7988235 | 0.74 | HRH3 (0.40) | HRH3APEX1GRK6ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |