Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386655 | 0.93 | KDM4E (0.42) | GAAPOLBKDM4EALDH1A1ATM | |
| Oxalic Acid SCHEMBL7988233 | 0.81 | HRH3 (0.41) | POLBALDH1A1GRK6KMT2AMEN1 | |
| Oxalic Acid SCHEMBL7989028 | 0.80 | ATM (0.42) | GAAPOLBKDM4EALDH1A1ATM | |
| Oxalic Acid SCHEMBL7990786 | 0.80 | KDM4E (0.52) | GAAKDM4EALDH1A1L3MBTL1KMT2A | |
| Oxalic Acid SCHEMBL7990904 | 0.76 | RXFP1 (0.43) | GAAKDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL4379711 | 0.76 | HRH3 (0.43) | ALDH1A1GRK6KMT2AMEN1LMNA | |
| SCHEMBL13636333 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1LMNAHTT | |
| SCHEMBL7994747 | 0.74 | KDM4E (0.45) | GAAPOLBKDM4EALDH1A1ATM | |
| Oxalic Acid SCHEMBL7977323 | 0.74 | HRH3 (0.43) | POLBKDM4EALDH1A1GRK6KMT2A | |
| SCHEMBL4379848 | 0.74 | KMT2A (0.38) | POLBKDM4EALDH1A1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |