SCHEMBL7988846

SCHEMBL7988846

O=C1OC(=O)c2cc3c(ccc4ccccc43)cc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.58
HSD17B10 Q99714 6/20 0.58
HIF1A Q16665 2/20 0.58
CYP1B1 Q16678 1/20 0.58
TSHR P16473 4/20 0.48
TDP1 Q9NUW8 3/20 0.48
CYP2A6 P11509 1/20 0.48
PAX8 Q06710 1/20 0.47
ALOX15 P16050 2/20 0.44
HPRT1 P00492 1/20 0.44
HPGD P15428 6/20 0.44
CYP1A2 P05177 1/20 0.44
KDM4E B2RXH2 4/20 0.43
MAPT P10636 3/20 0.43
CASP1 P29466 2/20 0.43
SIRT2 Q8IXJ6 1/20 0.43
SIRT1 Q96EB6 1/20 0.43
CASP7 P55210 1/20 0.43
GLA P06280 2/20 0.42
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7653329 0.82 ALDH1A1 (0.60) ALDH1A1HSD17B10HIF1ACYP1B1TSHR
SCHEMBL15024600 0.81 CES1 (0.46) ALDH1A1HSD17B10TDP1ALOX15HPGD
SCHEMBL30083328 0.80 ALOX15 (0.60) ALDH1A1HSD17B10HIF1ATSHRTDP1
SCHEMBL103 0.80 ALOX15 (0.60) ALDH1A1HSD17B10HIF1ATSHRTDP1
Chrysene SCHEMBL28227267 0.79 TDP1 (0.61) ALDH1A1HSD17B10HIF1ACYP1B1TSHR
SCHEMBL19753962 0.78 ALOX15 (0.38) ALDH1A1HSD17B10HIF1ACYP1B1TDP1
SCHEMBL7648181 0.78 ALDH1A1 (0.56) ALDH1A1HSD17B10HIF1ACYP1B1TSHR
SCHEMBL2700387 0.77 DNMT1 (0.59) ALDH1A1HSD17B10HIF1ACYP1B1TSHR
SCHEMBL9041820 0.77 ALDH1A1 (0.63) ALDH1A1HSD17B10HIF1ACYP1B1TSHR
SCHEMBL769280 0.76 ALOX15 (0.55) ALDH1A1HSD17B10HIF1ATSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2617578-B1 HEAT-SENSITIVE CHROMOGENIC COMPOSITION AND HEAT-SENSITIVE RECORDING MATERIAL FORMED USING SAID COMPOSITION YAMAMOTO CHEMICALS INC (JP) 2015-02-25 EP disclosed
US-8888906-B2 Heat-sensitive color-developing composition and heat-sensitive recording material comprising the composition YAMAMOTO CHEMICALS, INC. (JP) 2014-11-18 US disclosed
US-8888906-B2 Heat-sensitive color-developing composition and heat-sensitive recording material comprising the composition YAMAMOTO CHEMICALS, INC. (JP) 2014-11-18 US disclosed
EP-2617578-A1 HEAT-SENSITIVE CHROMOGENIC COMPOSITION AND HEAT-SENSITIVE RECORDING MATERIAL FORMED USING SAID COMPOSITION Yamamoto Chemicals, Inc. (JP) 2013-07-24 EP disclosed
US-20130180430-A1 HEAT-SENSITIVE COLOR-DEVELOPING COMPOSITION AND HEAT-SENSITIVE RECORDING MATERIAL COMPRISING THE COMPOSITION YAMAMOTO CHEMICALS, INC. (JP) 2013-07-18 US disclosed
US-20130180430-A1 HEAT-SENSITIVE COLOR-DEVELOPING COMPOSITION AND HEAT-SENSITIVE RECORDING MATERIAL COMPRISING THE COMPOSITION YAMAMOTO CHEMICALS, INC. (JP) 2013-07-18 US disclosed
US-6300340-B1 USEFUL FOR THERAPY OF CANCER AND SOLID TUMORS ADIR ET COMPAGNIE (FR) 2001-10-09 US disclosed
US-6162822-A Bisimide compounds ADIR ET COMPAGNIE (FR) 2000-12-19 US disclosed
EP-0820985-B1 Bis imide derivatives, process for their preparation and pharmaceutical compositions containing them ADIR (FR) 2000-08-30 EP disclosed
EP-0820985-A1 Bis imide derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1998-01-28 EP disclosed