Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.65 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.57 |
| ▸ | FABP3 | P05413 | 1/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPRB | P23467 | 1/20 | 0.50 |
| ▸ | PTPRE | P23469 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.45 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.44 |
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
| ▸ | PTPRF | P10586 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11835239 | 0.87 | GPR35 (0.64) | GPR35PTPN1PTPRCPTPN2PTPRB | |
| SCHEMBL11540686 | 0.86 | GPR35 (0.61) | GPR35PBRM1FABP3FABP4PTPN1 | |
| SCHEMBL31488086 | 0.82 | PBRM1 (0.57) | PBRM1FABP3FABP4PLK1MEN1 | |
| SCHEMBL6801278 | 0.82 | PBRM1 (0.57) | PBRM1FABP3FABP4PLK1MEN1 | |
| SCHEMBL8645476 | 0.81 | GPR35 (0.68) | GPR35MEN1KMT2AALDH1A1 | |
| SCHEMBL7988900 | 0.80 | GPR35 (0.56) | GPR35PBRM1PTPN1PTPRCPTPN2 | |
| SCHEMBL1300625 | 0.79 | PBRM1 (0.54) | PBRM1FABP3FABP4PLK1FEN1 | |
| SCHEMBL10743969 | 0.79 | PLK1 (0.62) | PBRM1FABP3FABP4PLK1MEN1 | |
| SCHEMBL11395900 | 0.79 | GPR35 (1.00) | GPR35PTPN1PTPN2MEN1KMT2A | |
| SCHEMBL23466650 | 0.79 | GPR35 (0.65) | GPR35MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |