Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 6/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.45 |
| ▸ | MAP2 | P11137 | 1/20 | 0.45 |
| ▸ | GRK6 | P43250 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990026 | 0.88 | GCGR (0.44) | PIN1CHEK2GCGRMAPK13MAPK12 | |
| SCHEMBL7989599 | 0.85 | SIRT2 (0.52) | PARP1ALOX5ERCC1FEN1ERCC4 | |
| SCHEMBL7991890 | 0.85 | BRAF (0.48) | PARP1PIN1CHEK2GCGRMAPK13 | |
| SCHEMBL7989973 | 0.81 | GCGR (0.43) | ALOX5PIN1CHEK2GCGR | |
| SCHEMBL7989925 | 0.79 | MAPK14 (0.62) | ALOX5CHEK2GCGRMAPK13MAPK12 | |
| SCHEMBL7988519 | 0.79 | GCGR (0.43) | PIN1CHEK2GCGRMAPK13MAPK12 | |
| SCHEMBL7995605 | 0.79 | MEN1 (0.52) | PARP1ERCC1FEN1ERCC4 | |
| SCHEMBL7995390 | 0.76 | MAPK14 (0.48) | PARP1PIN1CHEK2GCGRMAPK13 | |
| SCHEMBL7995219 | 0.76 | RHEB (0.48) | PARP1ALOX5PIN1MAP2CHEK2 | |
| SCHEMBL7988555 | 0.76 | PARP1 (0.54) | PARP1ALOX5PIN1ERCC1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |