Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.48 |
| ▸ | MMP9 | P14780 | 10/20 | 0.47 |
| ▸ | MMP2 | P08253 | 7/20 | 0.47 |
| ▸ | MMP1 | P03956 | 6/20 | 0.47 |
| ▸ | MMP14 | P50281 | 5/20 | 0.47 |
| ▸ | MMP8 | P22894 | 3/20 | 0.47 |
| ▸ | MMP13 | P45452 | 3/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 4/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000592 | 0.87 | MMP9 (0.52) | EPHX2MMP9MMP2MMP1MMP14 | |
| SCHEMBL7990003 | 0.81 | MMP9 (0.65) | MMP9MMP2MMP1MMP8MMP13 | |
| SCHEMBL7999031 | 0.79 | MMP9 (0.66) | MMP9MMP2MMP1MMP14MMP8 | |
| SCHEMBL7598899 | 0.79 | MMP9 (0.66) | MMP9MMP2MMP1MMP14MMP8 | |
| SCHEMBL7583731 | 0.76 | MMP9 (0.45) | MMP9MMP2MMP1MMP14MMP8 | |
| SCHEMBL8003468 | 0.76 | MMP9 (0.57) | EPHX2MMP9MMP2MMP1MMP14 | |
| SCHEMBL7435170 | 0.76 | MMP9 (0.64) | MMP9MMP2MMP1MMP14MMP8 | |
| SCHEMBL7598896 | 0.76 | MMP9 (0.64) | MMP9MMP2MMP1MMP14MMP8 | |
| SCHEMBL8005101 | 0.75 | MMP9 (0.47) | MMP9MMP2MMP1MMP14MMP8 | |
| SCHEMBL8002269 | 0.74 | MMP2 (0.46) | MMP9MMP2MMP1MMP14MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | claimed |
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |