Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 19/20 | 0.47 |
| ▸ | MMP2 | P08253 | 18/20 | 0.47 |
| ▸ | MMP1 | P03956 | 11/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005771 | 0.93 | MMP9 (0.49) | MMP9MMP2MMP1CHEK1AURKA | |
| SCHEMBL7990333 | 0.88 | MMP9 (0.46) | MMP9MMP2MMP1CHEK1AURKA | |
| SCHEMBL7679568 | 0.87 | CHEK1 (0.60) | MMP9MMP2MMP1CHEK1AURKA | |
| SCHEMBL8005767 | 0.80 | MMP9 (0.48) | MMP9MMP2MMP1CHEK1AURKA | |
| SCHEMBL7676525 | 0.80 | CHEK1 (0.62) | MMP9MMP2MMP1CHEK1AURKA | |
| SCHEMBL7673479 | 0.78 | MMP2 (0.58) | MMP9MMP2MMP1 | |
| SCHEMBL8002342 | 0.78 | MMP2 (0.80) | MMP9MMP2MMP1 | |
| SCHEMBL7673930 | 0.74 | MMP2 (0.57) | MMP9MMP2MMP1CHEK1AURKA | |
| SCHEMBL7673781 | 0.74 | MMP9 (0.57) | MMP9MMP2MMP1CHEK1AURKA | |
| SCHEMBL7510249 | 0.74 | CHEK1 (0.65) | MMP9MMP2MMP1CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294573-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION | ABBOTT LABORATORIES | 2001-09-25 | — | — | US | disclosed |