Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 5/20 | 0.44 |
| ▸ | ACE | P12821 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807798 | 0.95 | MAPK1 (0.46) | MAPK1SMN1; SMN2ECE1ACEMEN1 | |
| SCHEMBL7976826 | 0.94 | MAPK1 (0.45) | MAPK1SMN1; SMN2ECE1ACEMEN1 | |
| SCHEMBL7986462 | 0.93 | MAPK1 (0.44) | MAPK1SMN1; SMN2ECE1ACEMEN1 | |
| SCHEMBL7993751 | 0.93 | TACR1 (0.48) | MAPK1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL8810898 | 0.88 | TACR1 (0.47) | MAPK1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL7988163 | 0.88 | SMN1; SMN2 (0.44) | MAPK1SMN1; SMN2MEN1KMT2ASCN9A | |
| SCHEMBL7990508 | 0.88 | SMN1; SMN2 (0.44) | MAPK1SMN1; SMN2MEN1KMT2ASCN9A | |
| SCHEMBL7994280 | 0.87 | TACR1 (0.46) | MAPK1SMN1; SMN2 | |
| SCHEMBL7986645 | 0.86 | TACR1 (0.45) | MAPK1SMN1; SMN2 | |
| SCHEMBL7989806 | 0.84 | EDNRA (0.40) | ACECTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |