Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | PTGFR | P43088 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986471 | 0.90 | EDNRA (0.54) | SIRT2EDNRA | |
| SCHEMBL7990492 | 0.89 | SIRT2 (0.44) | SIRT2EDNRA | |
| SCHEMBL8808383 | 0.80 | SIRT2 (0.46) | SIRT2 | |
| SCHEMBL7990231 | 0.76 | NMBR (0.54) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7975875 | 0.74 | MAPK9 (0.61) | MAPK9EDNRACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2003419 | 0.73 | SIRT2 (0.50) | SIRT2 | |
| SCHEMBL2003418 | 0.73 | SIRT2 (0.50) | SIRT2 | |
| SCHEMBL1997674 | 0.72 | SIRT2 (0.52) | SIRT2 | |
| SCHEMBL21690129 | 0.72 | SIRT2 (0.49) | SIRT2CYP1A2KIF11 | |
| SCHEMBL6773700 | 0.72 | SIRT2 (0.49) | SIRT2CYP1A2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |