Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637573 | 0.86 | KMT2A (0.60) | KMT2AMEN1PTGDR2L3MBTL1POLB | |
| SCHEMBL19335483 | 0.85 | PKM (0.47) | KMT2AMEN1HTTPKMSLC22A6 | |
| SCHEMBL12111023 | 0.83 | CREBBP (0.63) | KMT2AMEN1HTTPKML3MBTL1 | |
| SCHEMBL5907838 | 0.82 | KMT2A (0.73) | KMT2AMEN1HTTPOLBSMN1; SMN2 | |
| SCHEMBL29171621 | 0.81 | CREBBP (0.61) | KMT2AMEN1HTTPKML3MBTL1 | |
| SCHEMBL3014488 | 0.80 | PTGDR2 (0.53) | KMT2AMEN1PTGDR2PPARDCREBBP | |
| SCHEMBL9540583 | 0.80 | MAOB (0.60) | KMT2AMEN1HTTRAB9AL3MBTL1 | |
| SCHEMBL17037234 | 0.79 | ALDH1A1 (0.58) | KMT2AMEN1HTTPKMSLC22A6 | |
| SCHEMBL5533467 | 0.79 | FFAR1 (0.52) | KMT2AMEN1PTGDR2HTTPKM | |
| SCHEMBL7566116 | 0.79 | PTGDR2 (0.63) | KMT2AMEN1PTGDR2PKMCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |