Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 9/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550092 | 0.92 | KDR (0.49) | KDRFLT1FLT4PDE4BCNR2 | |
| SCHEMBL7990572 | 0.92 | KDR (0.50) | KDRFLT1FLT4PDE4BCNR2 | |
| SCHEMBL7990350 | 0.91 | KDR (0.55) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7976879 | 0.90 | KDR (0.50) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7987655 | 0.87 | KDR (0.51) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7553648 | 0.87 | KDR (0.50) | KDRFLT1FLT4CNR2MAPK13 | |
| SCHEMBL7549301 | 0.87 | KDR (0.52) | KDRFLT1FLT4CNR2MAPK13 | |
| SCHEMBL7550496 | 0.87 | CNR2 (0.38) | KDRFLT1FLT4PDE4BCNR2 | |
| SCHEMBL7987725 | 0.85 | KDR (0.70) | KDRFLT1FLT4CNR2GSK3B | |
| SCHEMBL7554271 | 0.84 | KDR (0.49) | KDRFLT1FLT4CNR2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |