Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4140012 | 0.81 | RAB9A (0.58) | ALDH1A1MAPK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL21323158 | 0.79 | TSHR (0.68) | ALDH1A1L3MBTL1MAPK1RAB9ANPC1 | |
| SCHEMBL20022971 | 0.78 | ALDH1A1 (0.63) | ALDH1A1RAB9ANPC1SMN1; SMN2MAOA | |
| SCHEMBL6784181 | 0.78 | ALDH1A1 (0.96) | ALDH1A1L3MBTL1MAPK1TSHRMGLL | |
| SCHEMBL19926744 | 0.78 | SMN1; SMN2 (0.57) | ALDH1A1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL286952 | 0.77 | ALDH1A1 (0.60) | ALDH1A1MAPK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27499661 | 0.77 | ALDH1A1 (0.92) | ALDH1A1L3MBTL1MAPK1LMNATSHR | |
| SCHEMBL7638188 | 0.77 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1MAPK1RAB9ANPC1 | |
| SCHEMBL361779 | 0.77 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1MAPK1LMNATSHR | |
| SCHEMBL8181400 | 0.76 | ALDH1A1 (0.56) | ALDH1A1RAB9ANPC1SMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |