Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.59 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | AIMP2 | Q13155 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389548 | 0.85 | LTB4R (0.47) | LTB4RLTB4R2HTTAIMP2POLB | |
| SCHEMBL14053644 | 0.78 | LTB4R (0.48) | LTB4RLTB4R2HTTAIMP2POLB | |
| SCHEMBL8785209 | 0.74 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL8785623 | 0.74 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL8785049 | 0.74 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL8785213 | 0.74 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL10387689 | 0.73 | CYP3A4 (0.51) | LTB4RLTB4R2HTTPOLBAKR1B1 | |
| SCHEMBL22068562 | 0.72 | CA2 (0.53) | LMNASMN1; SMN2DRD2DRD4DRD3 | |
| SCHEMBL29642680 | 0.72 | CYP3A4 (0.75) | HPGDCYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL286952 | 0.72 | ALDH1A1 (0.60) | HTTAKR1B1HPGDCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |