Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | NPY1R | P25929 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | NPY2R | P49146 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | THPO | P40225 | 1/20 | 0.68 |
| ▸ | ADK | P55263 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8826218 | 0.89 | LMNA (0.64) | LMNASLC29A1ALDH1A1GLAPMP22 | |
| SCHEMBL18486201 | 0.89 | SLC29A1 (0.57) | LMNASLC29A1ALDH1A1GLAPMP22 | |
| SCHEMBL18862688 | 0.88 | HIF1A (0.56) | LMNASLC29A1ALDH1A1GLAPMP22 | |
| SCHEMBL22349482 | 0.88 | HIF1A (0.56) | LMNASLC29A1ALDH1A1GLAPMP22 | |
| SCHEMBL23982135 | 0.86 | SLC29A1 (0.76) | SLC29A1SMN1; SMN2NPC1RAB9AHIF1A | |
| SCHEMBL2288114 | 0.86 | SLC29A1 (0.76) | SLC29A1SMN1; SMN2NPC1RAB9AHIF1A | |
| SCHEMBL21011278 | 0.86 | SLC29A1 (0.76) | SLC29A1SMN1; SMN2NPC1RAB9AHIF1A | |
| SCHEMBL2288108 | 0.86 | SLC29A1 (0.76) | SLC29A1SMN1; SMN2NPC1RAB9AHIF1A | |
| SCHEMBL14873532 | 0.86 | SLC29A1 (0.76) | SLC29A1SMN1; SMN2NPC1RAB9AHIF1A | |
| SCHEMBL23982158 | 0.86 | SLC29A1 (0.76) | SLC29A1SMN1; SMN2NPC1RAB9AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991412-A4 | AMINOACYL SULFAMIDES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CUBIST PHARM INC (US) | 2000-06-21 | — | — | EP | disclosed |
| EP-0991412-A1 | AMINOACYL SULFAMIDES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | Cubist Pharmaceuticals, Inc. (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998041215-A1 | AMINOACYL SULFAMIDES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | CUBIST PHARMACEUTICALS, INC. (US) | 1998-09-24 | — | — | WO | disclosed |