Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 16/20 | 0.60 |
| ▸ | LTB4R2 | Q9NPC1 | 16/20 | 0.60 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990584 | 1.00 | LTB4R (0.60) | LTB4RLTB4R2ELANEBRD4RORC | |
| SCHEMBL7990582 | 1.00 | LTB4R (0.60) | LTB4RLTB4R2ELANEBRD4RORC | |
| SCHEMBL7990421 | 0.84 | LTB4R (0.57) | LTB4RLTB4R2ELANEBRD4RORC | |
| SCHEMBL7990417 | 0.84 | LTB4R (0.57) | LTB4RLTB4R2ELANEBRD4RORC | |
| SCHEMBL7990424 | 0.84 | LTB4R (0.57) | LTB4RLTB4R2ELANEBRD4RORC | |
| SCHEMBL8420509 | 0.80 | MTNR1B (0.48) | LTB4RLTB4R2ELANE | |
| SCHEMBL8420508 | 0.80 | MTNR1B (0.48) | LTB4RLTB4R2ELANE | |
| SCHEMBL7987976 | 0.75 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7987975 | 0.75 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7987971 | 0.75 | LTB4R (1.00) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |