Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420509 | 1.00 | MTNR1B (0.48) | MTNR1BMTNR1AELANEPDE4APDE4B | |
| SCHEMBL8418466 | 0.85 | MEN1 (0.46) | MTNR1BMTNR1AELANEPDE4APDE4B | |
| SCHEMBL8418465 | 0.85 | MEN1 (0.46) | MTNR1BMTNR1AELANEPDE4APDE4B | |
| SCHEMBL7990580 | 0.80 | LTB4R (0.60) | ELANELTB4RLTB4R2 | |
| SCHEMBL7990582 | 0.80 | LTB4R (0.60) | ELANELTB4RLTB4R2 | |
| SCHEMBL7990584 | 0.80 | LTB4R (0.60) | ELANELTB4RLTB4R2 | |
| SCHEMBL21391358 | 0.75 | PTGER1 (0.54) | MTNR1BMTNR1AELANE | |
| SCHEMBL8564889 | 0.74 | LTB4R (0.68) | LTB4RLTB4R2 | |
| SCHEMBL9077759 | 0.73 | — | — | |
| SCHEMBL8420619 | 0.73 | LTB4R (0.67) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |