Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ECE1 | P42892 | 7/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976771 | 1.00 | MAPK1 (0.57) | MAPK1SMN1; SMN2ECE1MMP2MMP9 | |
| SCHEMBL7987457 | 0.87 | MAPK1 (0.57) | MAPK1SMN1; SMN2ECE1ACE | |
| SCHEMBL7989694 | 0.87 | MAPK1 (0.57) | MAPK1SMN1; SMN2ECE1ACE | |
| SCHEMBL8861653 | 0.84 | ECE1 (0.64) | ECE1MMP2MMP9MMP8ACE | |
| SCHEMBL7987497 | 0.84 | MAPK1 (0.58) | MAPK1SMN1; SMN2ECE1ACE | |
| SCHEMBL7994202 | 0.83 | ECE1 (0.60) | MAPK1SMN1; SMN2ECE1ACE | |
| SCHEMBL7990469 | 0.82 | MAPK1 (0.54) | MAPK1SMN1; SMN2ECE1ACE | |
| SCHEMBL15145331 | 0.82 | MEN1 (0.66) | MAPK1SMN1; SMN2MMP2MMP9MMP8 | |
| SCHEMBL7990023 | 0.82 | MAPK1 (0.56) | MAPK1SMN1; SMN2ECE1ACE | |
| SCHEMBL7993356 | 0.81 | ECE1 (0.59) | MAPK1SMN1; SMN2ECE1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |