SCHEMBL15145331

SCHEMBL15145331

O=C(CCc1ccc2c(c1)OCO2)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.66
KMT2A Q03164 3/20 0.66
NPSR1 Q6W5P4 1/20 0.66
HTT P42858 1/20 0.61
SMN1; SMN2 Q16637 2/20 0.58
MAPK1 P28482 1/20 0.58
MMP2 P08253 1/20 0.56
MMP9 P14780 1/20 0.56
MMP8 P22894 1/20 0.56
POLB P06746 1/20 0.54
MAPT P10636 1/20 0.54
THRB P10828 1/20 0.54
ALOX15 P16050 1/20 0.53
LMNA P02545 1/20 0.53
TP53 P04637 1/20 0.53
ACE P12821 2/20 0.53
ERAP2 Q6P179 1/20 0.53
ITGB2 P05107 1/20 0.52
ICAM1 P05362 1/20 0.52
ITGAL P20701 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2959306 0.86 ALOX15 (0.64) MEN1KMT2APOLBALOX15TP53
SCHEMBL28587519 0.86 ALOX15 (0.64) MEN1KMT2APOLBALOX15TP53
SCHEMBL2956712 0.86 ALOX15 (0.64) MEN1KMT2APOLBALOX15TP53
SCHEMBL15145377 0.85 ALOX15 (0.58) MEN1KMT2APOLBALOX15TP53
SCHEMBL8861653 0.83 ECE1 (0.64) MMP2MMP9MMP8ACE
SCHEMBL9727576 0.83 ITGB2 (0.66) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL9727891 0.83 ITGB2 (0.66) MEN1KMT2ASMN1; SMN2POLBMAPT
SCHEMBL7976771 0.82 MAPK1 (0.57) HTTSMN1; SMN2MAPK1MMP2MMP9
SCHEMBL7990777 0.82 MAPK1 (0.57) HTTSMN1; SMN2MAPK1MMP2MMP9
SCHEMBL7445244 0.81 NPC1 (0.61) SMN1; SMN2MAPTLMNAACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130196050-A1 SALTY TASTE ENHANCER AJINOMOTO CO., INC. (JP) 2013-08-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130196050-A1 SALTY TASTE ENHANCER TAS2R10, TAS2R5, TAS1R1 MEN1 2795/4885KMT2A 1560/4885NPSR1 1259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.