Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082085 | 0.85 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| Morpholine SCHEMBL4553714 | 0.82 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| Morpholine SCHEMBL7387653 | 0.78 | MAPK14 (0.39) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| SCHEMBL4566366 | 0.78 | ADORA2A (0.46) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| Morpholine SCHEMBL7419803 | 0.74 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12RIPK3 | |
| SCHEMBL4553711 | 0.74 | MAPK14 (0.55) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL7360193 | 0.74 | MAPK14 (0.55) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL7232352 | 0.74 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12ADORA2A | |
| SCHEMBL8524296 | 0.73 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12ALOX5 | |
| Morpholine SCHEMBL7382870 | 0.72 | ALOX5 (0.40) | MAPK14MAPK11MAPK13MAPK12RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288089-B1 | ADMINISTERING A COMPOSITION OF PYRIDYL IMIDAZOLE COMPOUNDS TO TREAT PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, ALZHEIMER'S DISEASE, AND AMYOTOPHIC LATERAL SCLEROSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-09-11 | — | — | US | claimed |