Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RNF4 | P78317 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451636 | 0.81 | NPC1 (0.67) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL14208428 | 0.76 | FFAR1 (0.44) | NPC1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7992091 | 0.74 | NPC1 (0.48) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL2931129 | 0.71 | ALDH1A1 (0.66) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL2902849 | 0.70 | NPC1 (0.62) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL8668061 | 0.70 | NPC1 (0.53) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL8668663 | 0.70 | NPC1 (0.53) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL4089947 | 0.69 | NPC1 (0.56) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL27498819 | 0.69 | NPC1 (0.60) | NPC1RAB9AALDH1A1HTTPAX8 | |
| SCHEMBL8670024 | 0.69 | RAB9A (0.51) | NPC1RAB9AALDH1A1HTTPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277871-B1 | ANTICANCER AGENTS | ABBOTT LABORATORIES | 2001-08-21 | — | — | US | disclosed |