Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451636 | 0.82 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL18292123 | 0.76 | RCE1 (0.47) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL7992011 | 0.74 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL8668663 | 0.74 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL9366937 | 0.73 | PLA2G4A (0.41) | SMN1; SMN2NR1H3PLA2G4ACES1L3MBTL1 | |
| SCHEMBL13110634 | 0.73 | NR1H3 (0.47) | ALDH1A1SMN1; SMN2NR1H3KDM4ETSHR | |
| SCHEMBL25383799 | 0.73 | ALOX5 (0.65) | SMN1; SMN2TNKSTNKS2PLA2G4ACES1 | |
| SCHEMBL8670024 | 0.72 | RAB9A (0.51) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL2931129 | 0.72 | ALDH1A1 (0.66) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL17925491 | 0.72 | KCNA5 (0.48) | NPC1RAB9AMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277871-B1 | ANTICANCER AGENTS | ABBOTT LABORATORIES | 2001-08-21 | — | — | US | disclosed |