Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 17/20 | 0.42 |
| ▸ | CA2 | P00918 | 17/20 | 0.42 |
| ▸ | CA9 | Q16790 | 15/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 12/20 | 0.38 |
| ▸ | CA7 | P43166 | 9/20 | 0.38 |
| ▸ | CA4 | P22748 | 5/20 | 0.38 |
| ▸ | CA5A | P35218 | 5/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262644 | 0.68 | ATM (0.46) | CA1CA2CA9CA12CA7 | |
| SCHEMBL4321937 | 0.65 | CA2 (0.45) | CA1CA2CA9CA12CA7 | |
| SCHEMBL4911529 | 0.63 | LTA4H (0.33) | CA1CA2CA9CA5ACA5B | |
| Diphenylether SCHEMBL28109377 | 0.62 | CA1 (0.71) | CA1CA2CA9SOS1CA12 | |
| SCHEMBL4913740 | 0.62 | MAOA (0.35) | CA1CA2CA9CA4 | |
| Phenylsulfamate SCHEMBL605969 | 0.61 | CA2 (1.00) | CA1CA2CA9CA12STS | |
| Diphenylether SCHEMBL27837900 | 0.60 | SOS1 (0.88) | CA1CA2CA9SOS1CA12 | |
| Benzenesulfonamide SCHEMBL27806846 | 0.60 | CA2 (0.94) | CA1CA2CA9SOS1CA12 | |
| Phenylsulfamate SCHEMBL4592853 | 0.59 | CA2 (0.95) | CA1CA2CA9CA12STS | |
| Phenylsulfamate SCHEMBL3213804 | 0.59 | CA2 (0.95) | CA1CA2CA9CA12STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331637-B1 | N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION | 2001-12-18 | — | — | US | disclosed |