Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12552411 | 0.88 | P2RX3 (0.38) | ABL1LCKP2RX3 | |
| SCHEMBL1964398 | 0.81 | ALDH1A1 (0.38) | ABL1LCKP2RX3MAPTKDM4E | |
| SCHEMBL8002482 | 0.70 | SMN1; SMN2 (0.37) | LCKP2RX3MAPTSMN1; SMN2GABRA2 | |
| SCHEMBL7992244 | 0.69 | FAAH (0.37) | ABL1 | |
| SCHEMBL20878463 | 0.67 | MAP3K5 (0.53) | ABL1LCKDYRK1A | |
| SCHEMBL8004695 | 0.66 | ABL1 (0.38) | ABL1LCKDYRK1AMAPTGAA | |
| SCHEMBL22395249 | 0.66 | LCK (0.51) | LCKMAPTGABRA1GABRG2GABRB3 | |
| SCHEMBL16417282 | 0.65 | MAPK1 (0.59) | LCKDYRK1AMAPTKDM4EALDH1A1 | |
| SCHEMBL22396462 | 0.64 | LCK (0.49) | LCKMAPTSMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL18366385 | 0.64 | NOTUM (0.43) | ABL1LCKMAPTGABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151991-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |