Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1086239 | 0.85 | GPR119 (0.43) | ROCK2GPR119HDAC1HDAC8HDAC6 | |
| SCHEMBL1086688 | 0.85 | OPRD1 (0.50) | MGLLGPR119TACR1HDAC1HDAC8 | |
| SCHEMBL12184398 | 0.85 | GPR119 (0.45) | ROCK2GPR119HDAC1HDAC8HDAC6 | |
| SCHEMBL1086247 | 0.83 | GPR119 (0.45) | GPR119TACR1HDAC1HDAC8HDAC6 | |
| SCHEMBL1086563 | 0.82 | MEN1 (0.47) | — | |
| SCHEMBL18422018 | 0.81 | MGLL (0.47) | MGLLGPR119TACR1HDAC1HDAC8 | |
| SCHEMBL7844898 | 0.80 | TACR1 (0.47) | ROCK2AMPD2TACR1HCRTR1HCRTR2 | |
| SCHEMBL1086929 | 0.79 | MGLL (0.45) | MGLLENPP2 | |
| SCHEMBL12184200 | 0.79 | HDAC1 (0.52) | GPR119HDAC1HDAC8HDAC6 | |
| SCHEMBL1086449 | 0.78 | MGLL (0.44) | MGLLAMPD2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172076-B1 | HETEROCYCLE-SUBSTITUTED 1,3,8-TRIAZASPIRO(4,5)DECANE DERIVATIVES; TREATING ARTERIOSCLEROSIS | MERCK & CO., INC. | 2001-01-09 | — | — | US | disclosed |