SCHEMBL7992970

SCHEMBL7992970

CCc1ccccc1N(CC(=O)O)C(=O)CCCc1ccncc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.42
HDAC3 O15379 1/20 0.42
MAPK1 P28482 1/20 0.42
ADRA1A P35348 1/20 0.42
HDAC4 P56524 1/20 0.42
SLC6A3 Q01959 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
ALOX5 P09917 5/20 0.42
KDR P35968 1/20 0.40
LTB4R2 Q9NPC1 2/20 0.40
KDM4A O75164 1/20 0.39
KDM5A P29375 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8492944 0.87 MEN1 (0.42) ALOX5KDRMLYCD
SCHEMBL7206701 0.79 RAB9A (0.45) SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL7380533 0.77 ALOX5 (0.45) SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL7992967 0.76 ALOX5 (0.56) SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL10691678 0.72 ALOX5 (0.61) SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL1624984 0.71 HDAC3 (0.67) SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL2201636 0.70 ALOX5 (0.55) SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL7862392 0.70 ALOX5 (0.48) MAPK1ALOX5
Hydrochloric Acid SCHEMBL6644828 0.70 HDAC3 (0.64) SMN1; SMN2HDAC3MAPK1ADRA1AHDAC4
SCHEMBL15483886 0.68 TDP1 (0.54)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6294549-B1 COMPOUNDS USEFUL FOR INHIBITING RESTENOSIS, ANGIOGENESIS, ATHEROSCLEROSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, INFLAMMATION OR TUMOR GROWTH. MERCK & CO., INC. 2001-09-25 US disclosed