Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374440 | 0.84 | ALOX5 (0.58) | ALOX5HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL7206701 | 0.83 | RAB9A (0.45) | ALOX5HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL15062810 | 0.81 | KDM4A (0.61) | ALOX5HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL1677783 | 0.79 | CA12 (0.55) | ALOX5CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7380533 | 0.78 | ALOX5 (0.45) | ALOX5HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL7444522 | 0.77 | MAPT (0.68) | ALOX5HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL11241052 | 0.77 | TDP1 (0.57) | ALOX5HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL7992970 | 0.76 | SMN1; SMN2 (0.42) | ALOX5HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL21837731 | 0.76 | TDP1 (0.49) | ALOX5HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL6359725 | 0.75 | TDP1 (0.58) | ALOX5HDAC3MAPK1ADRA1AHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294549-B1 | COMPOUNDS USEFUL FOR INHIBITING RESTENOSIS, ANGIOGENESIS, ATHEROSCLEROSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, INFLAMMATION OR TUMOR GROWTH. | MERCK & CO., INC. | 2001-09-25 | — | — | US | disclosed |