Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982783 | 0.80 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL7996991 | 0.79 | CSNK1A1 (0.53) | AURKBAURKATPX2MAPK14MAPK13 | |
| SCHEMBL5260080 | 0.79 | MAPK14 (0.49) | AURKBAURKATPX2MAPK14MAPK13 | |
| SCHEMBL7997004 | 0.74 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5850146 | 0.73 | MAPK14 (0.49) | AURKBAURKATPX2MAPK14MAPK13 | |
| SCHEMBL8000327 | 0.73 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL10290856 | 0.72 | CSNK1D (0.54) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL6752469 | 0.72 | MAPK14 (0.52) | AURKBAURKATPX2MAPK14MAPK13 | |
| SCHEMBL10290368 | 0.71 | CSNK1D (0.53) | MAPK14MAPK13MAPK12MAPK11GSK3B | |
| SCHEMBL5316895 | 0.71 | TDP1 (0.63) | AURKBAURKAMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | claimed |
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |