Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579207 | 0.83 | MAPK14 (0.53) | MAPK14CSNK1DJAK3CSNK1ECCNA2 | |
| SCHEMBL7993156 | 0.80 | AURKB (0.49) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL1554639 | 0.79 | MAPK14 (0.54) | MAPK14CSNK1DJAK3CSNK1ECCNA2 | |
| SCHEMBL21621304 | 0.78 | L3MBTL1 (0.58) | MAPK14CSNK1DJAK3CSNK1ECCNA2 | |
| SCHEMBL5799690 | 0.75 | MAPK14 (0.57) | MAPK14CSNK1DJAK3CSNK1ECCNA2 | |
| SCHEMBL3573674 | 0.75 | LMNA (0.50) | MAPK14CSNK1DJAK3CSNK1ECCNA2 | |
| SCHEMBL4974887 | 0.75 | MAPK14 (0.81) | MAPK14CSNK1DJAK3MAPK13MAPK12 | |
| SCHEMBL7997004 | 0.74 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL1554892 | 0.73 | CSNK1E (0.50) | MAPK14CSNK1DJAK3CSNK1ECCNA2 | |
| SCHEMBL6643486 | 0.73 | CSNK1E (0.53) | MAPK14CSNK1DJAK3CSNK1ECCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | claimed |
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |