Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 2/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996541 | 0.83 | ADORA2B (0.46) | MAPK14MAPK13MAPK12MAPK11ADORA2B | |
| SCHEMBL8000327 | 0.82 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11ADORA2B | |
| SCHEMBL8000428 | 0.81 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL7993156 | 0.74 | AURKB (0.49) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7982783 | 0.74 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL4101681 | 0.70 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11ADORA2B | |
| SCHEMBL5378766 | 0.69 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11ADORA2B | |
| SCHEMBL7982929 | 0.68 | TDP1 (0.45) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL21067592 | 0.68 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11ADORA2B | |
| SCHEMBL7993062 | 0.68 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | claimed |
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |