Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.50 |
| ▸ | GCGR | P47871 | 5/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982929 | 0.84 | TDP1 (0.45) | MAPK14MAPK10SRCBRAFKDR | |
| SCHEMBL7993062 | 0.84 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7997004 | 0.82 | MAPK14 (0.48) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL7996121 | 0.81 | MAPK14 (0.53) | MAPK14SRCBRAFKDRMAPK13 | |
| SCHEMBL7997046 | 0.75 | MAPK11 (0.54) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7983814 | 0.75 | MAPK14 (0.57) | MAPK14KDRMAPK13MAPK12MAPK11 | |
| SCHEMBL7982783 | 0.73 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL7993156 | 0.73 | AURKB (0.49) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6932744 | 0.72 | MAPK14 (0.67) | MAPK14MAPK10BRAFMAPK13MAPK12 | |
| SCHEMBL9937001 | 0.70 | NOTUM (0.58) | MAPK14BRAFMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | claimed |
| WO-2001057018-A1 | AZAAZULENE INHIBITORS OF P38 MAP KINASE AND TNF-ALPHA | ABBOTT LABORATORIES (US) | 2001-08-09 | — | — | WO | disclosed |