Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | PYGL | P06737 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31504019 | 0.90 | KDM4E (0.72) | MEN1KMT2AALDH1A1POLBKDM4E | |
| SCHEMBL31103641 | 0.88 | MEN1 (0.76) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL1572442 | 0.88 | MEN1 (0.76) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL27858189 | 0.86 | MEN1 (0.74) | MEN1KMT2AALDH1A1POLBMAPT | |
| Methane SCHEMBL28043489 | 0.86 | MEN1 (0.74) | MEN1KMT2AALDH1A1POLBMAPT | |
| Fluoride SCHEMBL28307367 | 0.86 | MEN1 (0.74) | MEN1KMT2AALDH1A1POLBMAPT | |
| Ammonia Solution, Strong SCHEMBL27704150 | 0.86 | MEN1 (0.74) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL31504028 | 0.85 | MEN1 (0.62) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL2436534 | 0.84 | L3MBTL1 (0.65) | MEN1KMT2AALDH1A1POLBRAB9A | |
| SCHEMBL3506913 | 0.84 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0841919-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-24 | — | — | EP | disclosed |
| EP-0841919-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5710171-A | ANTICANCER AND ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996037204-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-11-28 | — | — | WO | disclosed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |