Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TXN | P10599 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.33 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10615777 | 0.83 | CA2 (0.43) | NPC1RAB9AKMT2AALDH1A1MMP3 | |
| SCHEMBL647802 | 0.79 | NPC1 (0.44) | NPC1RAB9AKMT2ATXNTXNRD1 | |
| SCHEMBL10617270 | 0.79 | NPC1 (0.41) | NPC1RAB9AKMT2AFPR2MMP3 | |
| SCHEMBL5161109 | 0.78 | NPC1 (0.42) | NPC1RAB9AKMT2ATXNTXNRD1 | |
| SCHEMBL6666888 | 0.74 | NPC1 (0.49) | NPC1RAB9AKMT2AFPR2HSPA5 | |
| SCHEMBL6281989 | 0.74 | NPC1 (0.47) | NPC1RAB9AKMT2AHSPA5ALDH1A1 | |
| SCHEMBL7899576 | 0.73 | NPC1 (0.38) | NPC1RAB9AKMT2AHSPA5SMN1; SMN2 | |
| SCHEMBL28882574 | 0.73 | NPC1 (0.47) | NPC1RAB9AKMT2AFPR2HSPA5 | |
| SCHEMBL7196095 | 0.72 | NPC1 (0.46) | NPC1RAB9AKMT2AHSPA5ALDH1A1 | |
| SCHEMBL2321138 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6320040-B1 | PREPARING NOVEL NUCLEOSIDE OLIGOMERS BEARING PENDANT CONJUGATE GROUPS FOR INCORPORATION INTO NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. | 2001-11-20 | — | — | US | disclosed |
| US-5998603-A | TETRAHYDROFURANYL COMPOUNDS ARE PROVIDED THAT ARE FUNCTIONALIZED TO INCLUDE PENDANT CONJUGATE GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5688941-A | Methods of making conjugated 4' desmethyl nucleoside analog compounds | ISIS PHARMACEUTICALS, INC. (US) | 1997-11-18 | — | — | US | disclosed |
| US-5608046-A | Conjugated 4'-desmethyl nucleoside analog compounds | ISIS PHARMACEUTICALS, INC. (US) | 1997-03-04 | — | — | US | disclosed |
| WO-1996010030-A1 | OLIGOMERS HAVING HETEROATOM-LINKED CONJUGATE GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 1996-04-04 | — | — | WO | disclosed |