Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899574 | 0.75 | NPC1 (0.37) | NPC1RAB9AKMT2APRMT5WDR77 | |
| SCHEMBL6281989 | 0.74 | NPC1 (0.47) | NPC1RAB9AKMT2ATBXAS1GLA | |
| SCHEMBL7993393 | 0.73 | NPC1 (0.41) | NPC1RAB9AKMT2AHSPA5SMN1; SMN2 | |
| SCHEMBL10615777 | 0.73 | CA2 (0.43) | NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL7196095 | 0.72 | NPC1 (0.46) | NPC1RAB9AKMT2APRMT5WDR77 | |
| SCHEMBL8781963 | 0.72 | NPC1 (0.37) | NPC1RAB9AKMT2ATBXAS1HSPA5 | |
| SCHEMBL7797221 | 0.71 | NPC1 (0.44) | NPC1RAB9AKMT2ATBXAS1GLA | |
| SCHEMBL6666888 | 0.71 | NPC1 (0.49) | NPC1RAB9AKMT2AGLAHSPA5 | |
| SCHEMBL50972 | 0.69 | NPC1 (0.43) | NPC1RAB9AKMT2APRMT5WDR77 | |
| SCHEMBL28882574 | 0.69 | NPC1 (0.47) | NPC1RAB9AKMT2AGLAHSPA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207862-B1 | PRECURSORS ARE CHIRAL 4-HYDROXYCARBOXAMIDES, 4-HYDROXYHYDROXAMIC ACIDS, OR 4-HYDROXYHYDRAZIDES PRODUCED FROM GAMMA-LACTONES, WHICH IN TURN ARE DERIVED FROM 1,4-DIOLS BY STEREOSELECTIVE OXIDATION, | BIOCATALYTICS, INC. | 2001-03-27 | — | — | US | disclosed |
| WO-1999032649-A1 | METHODS AND PRECURSORS FOR THE PRODUCTION OF CHIRAL 1,3-AMINOALCOHOLS | BIOCATALYTICS, INC. (US) | 1999-07-01 | — | — | WO | disclosed |
| US-5916786-A | Method for the production of chiral 1,3-aminoalcohols | BIOCATALYTICS, INC. (US) | 1999-06-29 | — | — | US | disclosed |