Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978917 | 0.86 | KCNH2 (0.62) | HTR7KCNH2HTR1AHTR6 | |
| SCHEMBL7978922 | 0.86 | KCNH2 (0.62) | HTR7KCNH2 | |
| SCHEMBL7991560 | 0.83 | HTR7 (0.66) | HTR7HTR1AHTR6 | |
| SCHEMBL7993273 | 0.81 | MAPT (0.46) | MAPTMAPK1HTR7KCNH2 | |
| Hydrochloric Acid SCHEMBL7997105 | 0.80 | MAPT (0.45) | MAPTMAPK1HTR7KCNH2 | |
| SCHEMBL7993118 | 0.73 | HTR1A (0.62) | HTR7HTR1AHTR6 | |
| SCHEMBL7993425 | 0.72 | HTR1A (0.39) | HTR7KCNH2HTR1AHTR6 | |
| SCHEMBL11377236 | 0.71 | MAPT (0.54) | MAPTMAPK1KCNH2 | |
| SCHEMBL10518909 | 0.69 | HTR1A (0.54) | HTR1A | |
| SCHEMBL17226456 | 0.69 | CHRNA7 (0.59) | MAPTMAPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284775-B1 | PSYCHOLOGICAL DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-09-04 | — | — | US | disclosed |
| US-5371087-A | Antipsychotic, analgesics, anticonvulsant and anxiolytic agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5229388-A | 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |