Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9666741 | 0.81 | HTR1A (0.40) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| SCHEMBL7978922 | 0.77 | KCNH2 (0.62) | DRD2KCNH2HTR7 | |
| SCHEMBL7978917 | 0.75 | KCNH2 (0.62) | HTR1ADRD2HTR2AKCNH2HTR7 | |
| SCHEMBL7993118 | 0.74 | HTR1A (0.62) | HTR1ADRD2ADRA1AADRA1BHTR7 | |
| SCHEMBL7993417 | 0.72 | MAPT (0.46) | HTR1AKCNH2HTR7HTR6 | |
| SCHEMBL7991560 | 0.72 | HTR7 (0.66) | HTR1ADRD2HTR2AADRA1AADRA1B | |
| SCHEMBL11377242 | 0.70 | HRH1 (0.48) | DRD2HRH1 | |
| SCHEMBL10518926 | 0.68 | HTR1A (0.46) | HTR1ADRD2HTR2AHTR2CADRA1A | |
| SCHEMBL10518915 | 0.67 | HTR1A (0.43) | HTR1ADRD2HTR2AADRA1AADRA1B | |
| SCHEMBL3436701 | 0.64 | GAA (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284775-B1 | PSYCHOLOGICAL DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-09-04 | — | — | US | disclosed |
| US-5371087-A | Antipsychotic, analgesics, anticonvulsant and anxiolytic agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5229388-A | 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |