Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.74 |
| ▸ | DRD4 | P21917 | 2/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7993860 | 0.93 | HTR2A (0.66) | HTR2ADRD4ADRA1AMAPTDRD2 | |
| Maleic Acid SCHEMBL7993854 | 0.93 | HTR2A (0.66) | HTR2ADRD4ADRA1AMAPTDRD2 | |
| SCHEMBL7679404 | 0.85 | DRD4 (1.00) | HTR2ADRD4ADRA1AMAPT | |
| SCHEMBL7993408 | 0.82 | HTR2A (0.65) | HTR2ADRD4ADRA1AMAPTDRD2 | |
| SCHEMBL7996802 | 0.81 | HTR2A (0.73) | HTR2ADRD4ADRA1AMAPTDRD2 | |
| SCHEMBL8671953 | 0.80 | HTR7 (0.51) | HTR2ADRD4DRD2HTR1A | |
| SCHEMBL7815509 | 0.77 | HTR2A (0.61) | HTR2ADRD4ADRA1AMAPTDRD2 | |
| Maleic Acid SCHEMBL9667377 | 0.76 | HTR2A (0.65) | HTR2ADRD4ADRA1AMAPTDRD2 | |
| Fumaric Acid SCHEMBL9667386 | 0.76 | HTR2A (0.65) | HTR2ADRD4ADRA1AMAPTDRD2 | |
| Maleic Acid SCHEMBL7979544 | 0.76 | DRD4 (0.88) | HTR2ADRD4ADRA1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284775-B1 | PSYCHOLOGICAL DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-09-04 | — | — | US | disclosed |
| US-5801186-A | ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-09-01 | — | — | US | disclosed |
| US-5371087-A | Antipsychotic, analgesics, anticonvulsant and anxiolytic agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5229388-A | 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |