Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.88 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.88 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7979548 | 1.00 | DRD4 (0.88) | DRD4HTR2AADRA1AMAPT | |
| Fumaric Acid SCHEMBL9667386 | 0.86 | HTR2A (0.65) | DRD4HTR2AADRA1AMAPT | |
| Maleic Acid SCHEMBL9667377 | 0.86 | HTR2A (0.65) | DRD4HTR2AADRA1AMAPT | |
| SCHEMBL9298366 | 0.84 | HTR2A (0.81) | DRD4HTR2AADRA1AMAPT | |
| Maleic Acid SCHEMBL7993854 | 0.83 | HTR2A (0.66) | DRD4HTR2AADRA1AMAPT | |
| Fumaric Acid SCHEMBL7993860 | 0.83 | HTR2A (0.66) | DRD4HTR2AADRA1AMAPT | |
| Hydrochloric Acid SCHEMBL7990183 | 0.83 | HTR2A (0.80) | DRD4HTR2AADRA1AMAPT | |
| SCHEMBL7679404 | 0.83 | DRD4 (1.00) | DRD4HTR2AADRA1AMAPT | |
| SCHEMBL7996802 | 0.79 | HTR2A (0.73) | DRD4HTR2AADRA1AMAPT | |
| Fumaric Acid SCHEMBL7835323 | 0.77 | ADRA1A (0.54) | DRD4HTR2AADRA1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284775-B1 | PSYCHOLOGICAL DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-09-04 | — | — | US | disclosed |
| US-5371087-A | Antipsychotic, analgesics, anticonvulsant and anxiolytic agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5229388-A | 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |