Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.64 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CCR9 | P51686 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255649 | 0.82 | CCR2 (0.55) | CCR2APEX1GPR35TSHRTDP1 | |
| SCHEMBL27964872 | 0.79 | CCR2 (0.58) | CCR2APEX1GPR35TSHRTDP1 | |
| SCHEMBL28294933 | 0.79 | CCR2 (0.55) | CCR2FDPSAPEX1GPR35TSHR | |
| SCHEMBL4204922 | 0.78 | CCR2 (0.72) | CCR2CCR9 | |
| SCHEMBL28079176 | 0.78 | CCR2 (0.54) | CCR2FDPSAPEX1POLBMCL1 | |
| SCHEMBL18247738 | 0.77 | FDPS (0.49) | CCR2FDPSGPR35CCR9POLB | |
| SCHEMBL18247448 | 0.77 | CCR2 (0.61) | CCR2FDPSGPR35CCR9POLB | |
| SCHEMBL19921311 | 0.75 | CCR2 (0.65) | CCR2FDPSGPR35POLBMCL1 | |
| SCHEMBL28720908 | 0.75 | FDPS (0.47) | CCR2FDPSGPR35CCR9POLB | |
| SCHEMBL1653950 | 0.74 | CCR2 (0.46) | CCR2TSHRPOLBALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102199148-A | Benzenesulfonamide derivatives and pharmaceutical compositions thereof | PURZER PHARMACEUTICAL CO LTD | 2011-09-28 | — | — | CN | disclosed |
| US-6294672-B1 | FOR THERAPY OF DIABETES, AND OTHER DISEASES WHERE THE INHIBITION OF GLUCONEOGENESIS, CONTROL OF BLOOD GLUCOSE LEVELS, REDUCTION IN GLYCOGEN STORES, OR REDUCTION IN INSULIN LEVELS IS BENEFICIAL | METABASIS THERAPEUTICS, INC. | 2001-09-25 | — | — | US | disclosed |
| US-6054587-A | ANTIDIABETIC AGENTS | METABASIS THERAPEUTICS, INC. (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1998039342-A1 | NOVEL INDOLE AND AZAINDOLE INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE | METABASIS THERAPEUTICS, INC. (US) | 1998-09-11 | — | — | WO | disclosed |