Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.40 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28293114 | 0.88 | CCR2 (0.42) | CCR2HRH4F10ALDH1A1MAPT | |
| SCHEMBL7993476 | 0.78 | CCR2 (0.64) | CCR2MCL1FDPSAPEX1POLB | |
| SCHEMBL27964872 | 0.71 | CCR2 (0.58) | CCR2MCL1APEX1POLBALDH1A1 | |
| SCHEMBL28294933 | 0.71 | CCR2 (0.55) | CCR2MCL1FDPSAPEX1POLB | |
| SCHEMBL3255649 | 0.71 | CCR2 (0.55) | CCR2MCL1APEX1HRH4POLB | |
| SCHEMBL4204922 | 0.70 | CCR2 (0.72) | CCR2 | |
| SCHEMBL28899709 | 0.68 | CCR2 (0.50) | CCR2MCL1APEX1POLBALDH1A1 | |
| SCHEMBL21313807 | 0.65 | CCR2 (0.52) | CCR2F10ALDH1A1 | |
| SCHEMBL7953990 | 0.65 | TSHR (0.46) | CCR2F10ALDH1A1MAPT | |
| SCHEMBL29406621 | 0.63 | CCR2 (0.46) | CCR2APEX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658625-B | Indole amide compounds as inhibitors of cellular necrosis | 株式会社LG化学 | 2019-05-03 | — | — | CN | disclosed |
| CN-105658625-A | Indole amide compound as inhibitor of necrosis | 株式会社LG生命科学 | 2016-06-08 | — | — | CN | disclosed |