SCHEMBL7987522

SCHEMBL7987522

CCc1nc(CC(C(=O)OCc2ccccc2)c2ccc3c(c2)OCO3)cn1C(=O)OC(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 8/20 0.47
ALDH1A1 P00352 3/20 0.40
TSHR P16473 2/20 0.40
MAPT P10636 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
NPC1 O15118 1/20 0.40
TP53 P04637 1/20 0.40
RAB9A P51151 1/20 0.40
ATM Q13315 1/20 0.40
ACE P12821 1/20 0.39
HRH4 Q9H3N8 1/20 0.39
MAOB P27338 2/20 0.38
MAOA P21397 1/20 0.38
CYP19A1 P11511 1/20 0.36
MEN1 O00255 2/20 0.36
HTT P42858 2/20 0.36
KMT2A Q03164 2/20 0.36
LMNA P02545 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7989782 0.92 EDNRA (0.44) EDNRAALDH1A1TSHRMAPTSMN1; SMN2
SCHEMBL7994654 0.92 EDNRA (0.44) EDNRAALDH1A1TSHRMAPTSMN1; SMN2
SCHEMBL7987573 0.88 EDNRA (0.44) EDNRAMAPTNPC1RAB9AMEN1
SCHEMBL7993751 0.84 TACR1 (0.48) ALDH1A1MAPTSMN1; SMN2TP53MEN1
SCHEMBL7986399 0.82 EDNRA (0.42) EDNRAALDH1A1MAPTKMT2A
SCHEMBL7986434 0.80 EDNRA (0.41) EDNRAALDH1A1MAPTKMT2A
SCHEMBL7989999 0.80 EDNRA (0.40) EDNRAACE
SCHEMBL7994192 0.80 EDNRA (0.41) EDNRAALDH1A1MAPT
SCHEMBL8810898 0.79 TACR1 (0.47) ALDH1A1MAPTSMN1; SMN2TP53MEN1
SCHEMBL7994175 0.78 EDNRA (0.35) EDNRAMAPTNPC1RAB9AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265403-B1 TYROSINE INHIBITORS MERCK & CO., INC. 2001-07-24 US disclosed
US-6207686-B1 FOR THERAPY OF HYPERTENSION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed