Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | EDNRA | P25101 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976080 | 0.86 | CYP3A4 (0.52) | NPC1RAB9AALDH1A1CYP3A4HPGD | |
| SCHEMBL31171631 | 0.84 | ACE (0.58) | ACETSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL31171638 | 0.84 | ACE (0.58) | ACETSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL7990089 | 0.82 | EDNRA (0.60) | ACETSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL27969720 | 0.81 | CYP3A4 (0.62) | ACETSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL27969666 | 0.81 | CYP3A4 (0.62) | ACETSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL7993516 | 0.79 | EDNRA (0.59) | ACETSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL7987491 | 0.79 | EDNRA (0.61) | ACETSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL4997864 | 0.78 | LMNA (0.59) | ACENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL7993185 | 0.77 | EDNRA (0.57) | ACETSHRNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |