Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4997864 | 0.86 | LMNA (0.59) | CYP3A4CYP2D6LMNAALDH1A1CYP1A2 | |
| SCHEMBL14377906 | 0.86 | CYP3A4 (0.61) | CYP3A4CYP2D6ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4329251 | 0.86 | CYP3A4 (0.61) | CYP3A4CYP2D6ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7993756 | 0.86 | ACE (0.53) | CYP3A4CYP2D6LMNAALDH1A1HPGD | |
| SCHEMBL30052034 | 0.79 | CYP3A4 (0.62) | CYP3A4CYP2D6LMNAALDH1A1CYP1A2 | |
| SCHEMBL2457093 | 0.79 | CYP3A4 (0.62) | CYP3A4CYP2D6LMNAALDH1A1CYP1A2 | |
| SCHEMBL8953616 | 0.79 | CYP3A4 (0.62) | CYP3A4CYP2D6LMNAALDH1A1CYP1A2 | |
| SCHEMBL7516082 | 0.79 | CYP3A4 (0.62) | CYP3A4CYP2D6LMNAALDH1A1CYP1A2 | |
| SCHEMBL9234310 | 0.79 | RAB9A (0.52) | CYP3A4CYP2D6LMNAALDH1A1CYP1A2 | |
| SCHEMBL7307051 | 0.78 | CYP3A4 (0.63) | CYP3A4CYP2D6LMNAALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |