Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993827 | 0.90 | DHPS (0.52) | IRAK4IRAK1 | |
| SCHEMBL7990484 | 0.83 | DHPS (0.44) | IRAK4 | |
| SCHEMBL7996803 | 0.81 | EDNRA (0.48) | IRAK4 | |
| SCHEMBL7993509 | 0.81 | DHPS (0.49) | — | |
| SCHEMBL4066782 | 0.81 | DHPS (0.66) | — | |
| SCHEMBL2640202 | 0.80 | EDNRA (0.52) | — | |
| SCHEMBL7979324 | 0.77 | DHPS (0.50) | — | |
| SCHEMBL4060909 | 0.74 | EDNRB (0.63) | — | |
| SCHEMBL4061140 | 0.73 | EDNRA (0.67) | — | |
| SCHEMBL7997001 | 0.73 | EDNRA (0.51) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |