Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | FLT1 | P17948 | 4/20 | 0.56 |
| ▸ | FLT4 | P35916 | 4/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548014 | 0.89 | KDR (0.43) | KDRFLT1FLT4GSK3BDRD2 | |
| SCHEMBL7546102 | 0.87 | KDR (0.75) | KDRFLT1FLT4CYP2A6GSK3B | |
| SCHEMBL7993940 | 0.87 | KDR (0.74) | KDRFLT1FLT4CYP2A6GSK3B | |
| SCHEMBL7553729 | 0.86 | KDR (0.40) | KDRFLT1FLT4GSK3BDRD4 | |
| SCHEMBL7990540 | 0.86 | KDR (0.75) | KDRFLT1FLT4CYP2A6GSK3B | |
| SCHEMBL7553655 | 0.85 | KDR (0.39) | KDRFLT1FLT4RPS6KB1AKT1 | |
| SCHEMBL7994055 | 0.84 | KDR (0.56) | KDRFLT1FLT4CYP2A6RPS6KB1 | |
| SCHEMBL7551721 | 0.84 | CHRNB1 (0.39) | KDRFLT1FLT4GSK3BMAOB | |
| SCHEMBL7549687 | 0.83 | AVPR1B (0.38) | KDRFLT1FLT4CYP3A4DRD2 | |
| SCHEMBL7990489 | 0.81 | KDR (0.75) | KDRFLT1FLT4CYP2A6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |