Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL28900020 | 0.77 | ALDH1A1 (0.67) | MAPTALDH1A1TDP1MYCNR4A1 | |
| Naphthalene SCHEMBL9279433 | 0.77 | ALDH1A1 (0.47) | AKT1MAPTALDH1A1PKMEGFR | |
| SCHEMBL13636983 | 0.75 | — | — | |
| SCHEMBL482716 | 0.75 | MAOA (0.60) | HDAC4HDAC7HDAC5NOX1MAOA | |
| SCHEMBL4571020 | 0.75 | MAOA (0.60) | HDAC4HDAC7HDAC5NOX1MAOA | |
| SCHEMBL29390564 | 0.75 | MAOA (0.60) | HDAC4HDAC7HDAC5NOX1MAOA | |
| Benzene SCHEMBL9744618 | 0.75 | LMNA (0.44) | AKT1ALDH1A1LMNATDP1ALOX15 | |
| Phthalic Acid SCHEMBL9722583 | 0.75 | ALDH1A1 (0.70) | MAPTALDH1A1TDP1MYCNR4A1 | |
| Toluene SCHEMBL8733082 | 0.75 | LMNA (0.55) | AKT1NPC1RAB9AMAPTALDH1A1 | |
| Phenol SCHEMBL28063923 | 0.75 | CA12 (0.55) | AKT1MAOANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0886803-A4 | IMPROVED ELECTROCHROMIC LAYER AND DEVICES COMPRISING SAME | GENTEX CORP (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0886803-A1 | IMPROVED ELECTROCHROMIC LAYER AND DEVICES COMPRISING SAME | GENTEX CORPORATION (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997034186-A1 | IMPROVED ELECTROCHROMIC LAYER AND DEVICES COMPRISING SAME | GENTEX CORPORATION (US) | 1997-09-18 | — | — | WO | disclosed |