Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995779 | 0.83 | PTGES (0.36) | PTGESALOX5PPARGPSEN1NPY2R | |
| SCHEMBL7998083 | 0.77 | LMNA (0.42) | PTGESALOX5PPARGNPY2RLMNA | |
| SCHEMBL8948324 | 0.75 | CCR6 (0.40) | NPY2RCHRNA7MAOBKDM1A | |
| SCHEMBL7995588 | 0.74 | DNMT1 (0.56) | SLC6A5DNMT1EHMT2 | |
| SCHEMBL7983659 | 0.73 | CYP1A1 (0.40) | NPY2RMEN1LMNAALOX12KMT2A | |
| SCHEMBL9114551 | 0.70 | LTA4H (0.48) | PTGESALOX5PPARGPSEN1MEN1 | |
| SCHEMBL9114548 | 0.70 | LTA4H (0.48) | PTGESALOX5PPARGPSEN1MEN1 | |
| SCHEMBL9116659 | 0.69 | LTA4H (0.47) | PTGESALOX5PPARGPSEN1MEN1 | |
| SCHEMBL9116652 | 0.69 | LTA4H (0.47) | PTGESALOX5PPARGPSEN1MEN1 | |
| SCHEMBL7994196 | 0.68 | DNMT1 (0.51) | MEN1KMT2ASLC6A5DNMT1EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912090-A4 | INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED ARYL) HYDROXYMETHYL]PIPERIDINIUM SALTS | FMC CORP (US) | 2000-05-17 | — | — | EP | disclosed |
| EP-0912090-A1 | INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4- BIS(SUBSTITUTED ARYL) HYDROXYMETHYL]PIPERIDINIUM SALTS | FMC CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| US-5795901-A | Insecticidal N-(substituted arylmethyl)-4- bis(substituted aryl)hydroxymethyl!piperidinium salts | FMC CORPORATION (US) | 1998-08-18 | — | — | US | disclosed |
| WO-1998000015-A1 | INSECTICIDAL N-(SUBSTITUTED ARYLMETHYL)-4-[BIS(SUBSTITUTED ARYL) HYDROXYMETHYL]PIPERIDINIUM SALTS | FMC CORPORATION (US) | 1998-01-08 | — | — | WO | disclosed |