Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7553606 | 0.92 | KDR (0.49) | KDRFLT1FLT4MKNK2ALDH1A1 | |
| SCHEMBL7549070 | 0.92 | KDR (0.49) | KDRFLT1FLT4MAOB | |
| SCHEMBL7990426 | 0.90 | KDR (0.54) | KDRFLT1FLT4METCNR2 | |
| SCHEMBL7986909 | 0.89 | KDR (0.57) | KDRFLT1FLT4LMNATSHR | |
| SCHEMBL7551474 | 0.86 | KDR (0.53) | KDRFLT1FLT4GSK3BMAOB | |
| SCHEMBL7548335 | 0.86 | KDR (0.51) | KDRFLT1FLT4ALDH1A1KDM4E | |
| SCHEMBL7553661 | 0.86 | SLC6A4 (0.40) | KDRFLT1FLT4MKNK2MAOB | |
| SCHEMBL7976639 | 0.85 | FLT1 (0.47) | KDRFLT1FLT4MKNK2ALDH1A1 | |
| SCHEMBL7986598 | 0.85 | KDR (0.53) | KDRFLT1FLT4ALDH1A1LMNA | |
| SCHEMBL7990662 | 0.85 | KDR (0.68) | KDRFLT1FLT4MKNK2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |