Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | FLT1 | P17948 | 3/20 | 0.53 |
| ▸ | FLT4 | P35916 | 3/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986909 | 0.92 | KDR (0.57) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7990426 | 0.91 | KDR (0.54) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7548475 | 0.91 | KDR (0.52) | KDRFLT1FLT4ALDH1A1GRIN1 | |
| SCHEMBL7553606 | 0.88 | KDR (0.49) | KDRFLT1FLT4GSK3BTSHR | |
| SCHEMBL7987083 | 0.87 | KDR (0.69) | KDRFLT1FLT4MAPK13MAPK12 | |
| SCHEMBL7990322 | 0.86 | KDR (0.73) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7554600 | 0.85 | KDR (0.54) | KDRFLT1FLT4MAPK13MAPK12 | |
| SCHEMBL7552023 | 0.85 | KDR (0.40) | KDRFLT1FLT4TSHRMEN1 | |
| SCHEMBL7976802 | 0.85 | KDR (0.59) | KDRFLT1FLT4MAPK13MAPK12 | |
| SCHEMBL7976928 | 0.85 | KDR (0.59) | KDRFLT1FLT4MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306865-B1 | SYNTHASE INHIBITORS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. | 2001-10-23 | — | — | US | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |