Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | FLT1 | P17948 | 3/20 | 0.54 |
| ▸ | FLT4 | P35916 | 3/20 | 0.54 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986909 | 0.93 | KDR (0.57) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7986598 | 0.91 | KDR (0.53) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7546351 | 0.91 | KDR (0.53) | KDRFLT1FLT4SCN2ASCN10A | |
| SCHEMBL7994332 | 0.90 | KDR (0.50) | KDRFLT1FLT4GSK3BMET | |
| SCHEMBL7990322 | 0.87 | KDR (0.73) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7548749 | 0.86 | KDR (0.72) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7555272 | 0.85 | KDR (0.55) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7547866 | 0.85 | KDR (0.40) | KDRFLT1FLT4CNR2CNR1 | |
| SCHEMBL7553606 | 0.85 | KDR (0.49) | KDRFLT1FLT4GSK3BSLC2A1 | |
| SCHEMBL7550729 | 0.84 | KDR (0.56) | KDRFLT1FLT4NFATC1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |