Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.30 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | GPR183 | P32249 | 1/20 | 0.30 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8572350 | 0.82 | — | — | |
| Tromethamine SCHEMBL19716179 | 0.77 | S1PR1 (0.44) | TNNC1SGPL1S1PR4S1PR1GPR183 | |
| Tromethamine SCHEMBL2582820 | 0.73 | MEN1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL5694600 | 0.73 | MEN1 (0.40) | MEN1LMNAKMT2A | |
| SCHEMBL4308456 | 0.70 | — | — | |
| Methane SCHEMBL28754334 | 0.68 | — | — | |
| Hydrogen Sulfide SCHEMBL27783712 | 0.68 | — | — | |
| SCHEMBL3993707 | 0.67 | — | — | |
| Chloromethane SCHEMBL9168626 | 0.66 | — | — | |
| Chloromethane SCHEMBL9165237 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951354-A4 | METALLOCENES FOR MULTIMETALLIC POLYMERIZATION CATALYSTS | MOBIL OIL CORP (US) | 2000-08-09 | — | — | EP | disclosed |
| EP-0951354-A1 | METALLOCENES FOR MULTIMETALLIC POLYMERIZATION CATALYSTS | MOBIL OIL CORPORATION (a New York corporation) (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998011986-A1 | METALLOCENES FOR MULTIMETALLIC POLYMERIZATION CATALYSTS | MOBIL OIL CORPORATION (US) | 1998-03-26 | — | — | WO | disclosed |